Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 20/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.88 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | APLNR | P35414 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | GLP1R | P43220 | 1/20 | 0.55 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.55 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4680257 | 1.00 | GNRHR (0.88) | GNRHRCYP3A4ADRB2APLNROPRK1 | |
| SCHEMBL1378902 | 0.92 | GNRHR (1.00) | GNRHRCYP3A4 | |
| SCHEMBL1378898 | 0.92 | GNRHR (1.00) | GNRHRCYP3A4 | |
| SCHEMBL4675846 | 0.85 | GNRHR (0.85) | GNRHRCYP3A4 | |
| SCHEMBL4675839 | 0.85 | GNRHR (0.85) | GNRHRCYP3A4 | |
| SCHEMBL4674695 | 0.84 | GNRHR (0.87) | GNRHRCYP3A4ADRB2APLNROPRK1 | |
| SCHEMBL4674691 | 0.84 | GNRHR (0.87) | GNRHRCYP3A4ADRB2APLNROPRK1 | |
| SCHEMBL2703136 | 0.82 | GNRHR (0.73) | GNRHRCYP3A4 | |
| SCHEMBL1378029 | 0.82 | GNRHR (1.00) | GNRHRCYP3A4ADRB2APLNROPRK1 | |
| SCHEMBL1378026 | 0.82 | GNRHR (1.00) | GNRHRCYP3A4ADRB2APLNROPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646389-B1 | PYRIMIDINE-2,4-DIONE DERIVATIVES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES INC (US) | 2008-09-10 | — | — | EP | disclosed |