SCHEMBL4682945

SCHEMBL4682945

CCN(CC1CCN(C(=O)N(C)C)CC1)C(C)Cc1cccc(C(F)(F)F)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMYD3 Q9H7B4 1/20 0.45
CYP2D6 P10635 1/20 0.42
KMT2A Q03164 2/20 0.42
ALDH1A1 P00352 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HTR2A P28223 2/20 0.41
HTR2B P41595 2/20 0.41
HTR2C P28335 1/20 0.41
MEN1 O00255 1/20 0.41
KIF11 P52732 1/20 0.41
DPP4 P27487 2/20 0.40
DPP7 Q9UHL4 2/20 0.40
DPP8 Q6V1X1 1/20 0.40
DPP9 Q86TI2 1/20 0.40
TEAD1 P28347 2/20 0.40
SIGMAR1 Q99720 1/20 0.40
POLB P06746 1/20 0.40
EPHX2 P34913 1/20 0.40
LMNA P02545 1/20 0.40
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4678950 0.92 SMYD3 (0.40) SMYD3CYP2D6KMT2AHTR2AHTR2B
SCHEMBL4678953 0.89 USP2 (0.42) SMYD3CYP2D6KMT2AALDH1A1SMN1; SMN2
SCHEMBL4679834 0.89 KMT2A (0.47) SMYD3CYP2D6KMT2AALDH1A1SMN1; SMN2
SCHEMBL4678708 0.88 CYP2D6 (0.42) CYP2D6TEAD1EPHX2
Hydrochloric Acid SCHEMBL4680927 0.88 KMT2A (0.46) SMYD3CYP2D6KMT2AALDH1A1SMN1; SMN2
SCHEMBL4679892 0.87 CYP2D6 (0.43) SMYD3CYP2D6KMT2AALDH1A1SMN1; SMN2
Hydrochloric Acid SCHEMBL4686034 0.86 CYP2D6 (0.43) SMYD3CYP2D6KMT2AALDH1A1SMN1; SMN2
Hydrochloric Acid SCHEMBL4683719 0.85 CYP3A4 (0.44) SMYD3
Hydrochloric Acid SCHEMBL4682881 0.85 EPHX2 (0.42) SMYD3CYP2D6KMT2AALDH1A1DPP4
Hydrochloric Acid SCHEMBL4686153 0.83 CYP2D6 (0.59) SMYD3CYP2D6KMT2AHTR2AHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1058680-B1 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS HOFFMANN LA ROCHE (CH) 2008-07-09 EP claimed
US-6319920-B1 MUSCARINIC RECEPTOR ANTAGONIST USED IN GASTROINTESTINAL, GENITOURINARY TRACT, RESPIRATORY TRACT, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM DISORDERS AND IN ANESTHESIOLOGY AND OPHTHALMOLOGY SYNTEX (U.S.A.) LLC 2001-11-20 US claimed
EP-1058680-B1 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS HOFFMANN LA ROCHE (CH) 2008-07-09 EP disclosed
US-6319920-B1 MUSCARINIC RECEPTOR ANTAGONIST USED IN GASTROINTESTINAL, GENITOURINARY TRACT, RESPIRATORY TRACT, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM DISORDERS AND IN ANESTHESIOLOGY AND OPHTHALMOLOGY SYNTEX (U.S.A.) LLC 2001-11-20 US disclosed
EP-1058680-A1 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2000-12-13 EP disclosed
WO-1999043657-A1 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 1999-09-02 WO disclosed