Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CXCR3 | P49682 | 13/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4685333 | 0.99 | CYP2D6 (0.60) | CYP2D6CXCR3MCHR1CHRM5MAPK14 | |
| SCHEMBL4679111 | 0.93 | CYP2D6 (0.52) | CYP2D6CXCR3MCHR1CHRM5MAPK14 | |
| SCHEMBL4679386 | 0.93 | CYP2D6 (0.70) | CYP2D6CXCR3MCHR1CHRM5MAPK14 | |
| Hydrochloric Acid SCHEMBL4682563 | 0.92 | CYP2D6 (0.51) | CYP2D6CXCR3MCHR1CHRM5MAPK14 | |
| Hydrochloric Acid SCHEMBL4683742 | 0.92 | CYP2D6 (0.69) | CYP2D6CXCR3MCHR1CHRM5MAPK14 | |
| Hydrochloric Acid SCHEMBL4685784 | 0.92 | CYP2D6 (0.69) | CYP2D6CXCR3MCHR1CHRM5MAPK14 | |
| Hydrochloric Acid SCHEMBL4680309 | 0.86 | CYP2D6 (0.47) | CYP2D6MAPK14SMN1; SMN2 | |
| SCHEMBL4678736 | 0.86 | CYP2D6 (0.53) | CYP2D6CXCR3MCHR1MAPK14 | |
| Hydrochloric Acid SCHEMBL4682541 | 0.85 | CYP2D6 (0.59) | CYP2D6CXCR3MCHR1CHRM5MAPK14 | |
| SCHEMBL4678837 | 0.83 | CYP2D6 (0.86) | CYP2D6CXCR3MCHR1CHRM5MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1058680-B1 | 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | claimed |
| US-6319920-B1 | MUSCARINIC RECEPTOR ANTAGONIST USED IN GASTROINTESTINAL, GENITOURINARY TRACT, RESPIRATORY TRACT, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM DISORDERS AND IN ANESTHESIOLOGY AND OPHTHALMOLOGY | SYNTEX (U.S.A.) LLC | 2001-11-20 | — | — | US | claimed |
| EP-1058680-B1 | 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | disclosed |
| US-6319920-B1 | MUSCARINIC RECEPTOR ANTAGONIST USED IN GASTROINTESTINAL, GENITOURINARY TRACT, RESPIRATORY TRACT, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM DISORDERS AND IN ANESTHESIOLOGY AND OPHTHALMOLOGY | SYNTEX (U.S.A.) LLC | 2001-11-20 | — | — | US | disclosed |