Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 20/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3561381 | 0.89 | PTGER4 (0.79) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL2295587 | 0.84 | PTGER4 (0.79) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL3570750 | 0.81 | PTGER4 (1.00) | PTGER4 | |
| SCHEMBL2300769 | 0.80 | PTGER4 (1.00) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL3566802 | 0.79 | PTGER4 (0.80) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL3563657 | 0.77 | PTGER4 (1.00) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL3560192 | 0.77 | PTGER4 (1.00) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL2295490 | 0.77 | PTGER4 (1.00) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL12011135 | 0.77 | PTGER4 (0.65) | PTGER4 | |
| SCHEMBL3569590 | 0.77 | PTGER4 (0.82) | PTGER4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1886993-B1 | BENZO[F]ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR | GLAXO GROUP LTD (GB) | 2013-09-18 | — | — | EP | disclosed |
| EP-1886993-A1 | BENZO[F]ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2008-02-13 | — | — | EP | disclosed |