Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPN1 | P15169 | 2/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.42 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.32 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 4/20 | 0.32 |
| ▸ | NOS1 | P29475 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10447282 | 0.78 | TP53 (0.48) | LMNASMN1; SMN2KDM4EMAPTTP53 | |
| SCHEMBL27615745 | 0.78 | — | — | |
| SCHEMBL28010969 | 0.78 | TP53 (0.48) | LMNASMN1; SMN2KDM4EMAPTTP53 | |
| SCHEMBL28974097 | 0.78 | TP53 (0.48) | LMNASMN1; SMN2KDM4EMAPTTP53 | |
| SCHEMBL6371310 | 0.77 | CPN1 (0.47) | CPN1CPB2SLC6A1SLC6A11TSHR | |
| SCHEMBL29332274 | 0.77 | CPN1 (0.47) | CPN1CPB2SLC6A1SLC6A11TSHR | |
| SCHEMBL4683222 | 0.77 | CPN1 (0.36) | CPN1CPB2NOS2NOS1TP53 | |
| Trifluoroacetic Acid SCHEMBL34474854 | 0.77 | CPN1 (0.33) | CPN1CPB2SLC6A1SLC6A11SLC6A13 | |
| SCHEMBL4983448 | 0.77 | TP53 (0.52) | LMNASMN1; SMN2KDM4EMAPTTP53 | |
| SCHEMBL27927042 | 0.76 | CPN1 (0.37) | CPN1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1381599-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-09-24 | — | — | EP | claimed |
| EP-1453492-B1 | USE OF QUINAZOLINES TO TREAT T-CELL MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2007-01-24 | — | — | EP | claimed |
| EP-1409481-B1 | QUINOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-10-04 | — | — | EP | claimed |