Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 11/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MC5R | P33032 | 2/20 | 0.41 |
| ▸ | MC3R | P41968 | 2/20 | 0.41 |
| ▸ | MC1R | Q01726 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4510268 | 0.91 | MC4R (0.47) | MC4RHTTSMN1; SMN2NPSR1MC5R | |
| SCHEMBL4514985 | 0.87 | MC4R (0.49) | MC4RMC5RMC3RMC1RKMT2A | |
| SCHEMBL4509514 | 0.84 | MC4R (0.50) | MC4RMC5RMC3RMC1RKMT2A | |
| SCHEMBL4511084 | 0.84 | MC4R (0.49) | MC4RMC5RMC3RMC1RKMT2A | |
| SCHEMBL4525703 | 0.83 | KDM4E (0.48) | MC4RSMN1; SMN2NPSR1MC5RMC3R | |
| SCHEMBL4510034 | 0.82 | MC4R (0.52) | MC4RMC5RMC3RMC1RKMT2A | |
| SCHEMBL4515752 | 0.82 | MC4R (0.51) | MC4RMC5RMC3RMC1RKMT2A | |
| SCHEMBL4519772 | 0.82 | MC4R (0.58) | MC4RMC5RMC3RMC1RKMT2A | |
| SCHEMBL4528335 | 0.82 | MC4R (0.47) | MC4RMC5RMC3RMC1RMCL1 | |
| SCHEMBL4517009 | 0.81 | MC4R (0.51) | MC4RMC5RMC3RMC1RKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417190-B1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC (US) | 2008-10-22 | — | — | EP | disclosed |