Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 7/20 | 0.50 |
| ▸ | CA2 | P00918 | 7/20 | 0.50 |
| ▸ | CA12 | O43570 | 4/20 | 0.50 |
| ▸ | CA9 | Q16790 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4275424 | 0.96 | CA1 (0.50) | CA1CA2CA12CA9TDP1 | |
| SCHEMBL11687632 | 0.91 | NPC1 (0.56) | CA1CA2CA12CA9TDP1 | |
| SCHEMBL31307113 | 0.83 | TDP1 (0.58) | CA1CA2CA12CA9TDP1 | |
| SCHEMBL917871 | 0.83 | TDP1 (0.54) | CA1CA2CA12CA9TDP1 | |
| SCHEMBL31307112 | 0.83 | TDP1 (0.54) | CA1CA2CA12CA9TDP1 | |
| SCHEMBL4275420 | 0.83 | CA1 (0.48) | CA1CA2CA12CA9TDP1 | |
| SCHEMBL937704 | 0.82 | TDP1 (0.53) | CA1CA2CA12CA9TDP1 | |
| SCHEMBL7272921 | 0.82 | TDP1 (0.56) | CA1CA2CA12CA9TDP1 | |
| SCHEMBL21482939 | 0.82 | TDP1 (0.53) | CA1CA2CA12CA9TDP1 | |
| SCHEMBL938186 | 0.82 | CA1 (0.55) | CA1CA2CA12CA9TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663235-A4 | CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS | PARION SCIENCES INC (US) | 2008-11-12 | — | — | EP | disclosed |
| EP-1663235-A1 | CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS | Parion Sciences, Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005018644-A1 | CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2005-03-03 | — | — | WO | disclosed |