Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.42 |
| ▸ | CTSS | P25774 | 3/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6352709 | 0.91 | AKT1 (0.48) | AKT1SYKL3MBTL1SMN1; SMN2CTSL | |
| SCHEMBL5368670 | 0.88 | AKT1 (0.53) | AKT1SYKL3MBTL1SMN1; SMN2CTSL | |
| SCHEMBL25274670 | 0.83 | AKT1 (0.52) | AKT1SYKSMN1; SMN2CTSLCTSS | |
| SCHEMBL2059357 | 0.82 | AKT1 (0.54) | AKT1SYKSMN1; SMN2CTSLCTSS | |
| SCHEMBL8432795 | 0.82 | AKT1 (0.56) | AKT1SYKSMN1; SMN2CTSLCTSS | |
| SCHEMBL6022135 | 0.80 | AKT1 (0.42) | AKT1SMN1; SMN2MAPTCA12CA1 | |
| SCHEMBL9756736 | 0.78 | AKT1 (0.53) | AKT1SYKSMN1; SMN2CTSLCTSS | |
| SCHEMBL25002520 | 0.76 | SYK (0.53) | AKT1SYKL3MBTL1SMN1; SMN2CTSL | |
| SCHEMBL32691073 | 0.76 | AKT1 (0.47) | AKT1SYKL3MBTL1SMN1; SMN2CTSL | |
| SCHEMBL31031058 | 0.76 | AKT1 (0.49) | AKT1SYKL3MBTL1SMN1; SMN2CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534292-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2008-04-02 | — | — | EP | disclosed |
| EP-1534292-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2003099844-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-12-04 | — | — | WO | disclosed |