Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.68 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.55 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.55 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.55 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.55 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.53 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.52 |
| ▸ | F2 | P00734 | 2/20 | 0.52 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4652513 | 0.93 | PARP10 (0.64) | PARP10PARP15PARP4ALDH1A1KMT2A | |
| SCHEMBL4654822 | 0.93 | PARP10 (0.64) | PARP10PARP15PARP4ALDH1A1KMT2A | |
| SCHEMBL27295340 | 0.93 | PARP10 (0.64) | PARP10PARP15PARP4ALDH1A1KMT2A | |
| SCHEMBL4652331 | 0.93 | PARP10 (0.64) | PARP10PARP15PARP4ALDH1A1KMT2A | |
| SCHEMBL77571 | 0.90 | PARP10 (0.70) | PARP10CHEK2PARP15PARP4ALDH1A1 | |
| SCHEMBL4687508 | 0.85 | PARP10 (0.68) | PARP10PARP15PARP4ALDH1A1KMT2A | |
| Water SCHEMBL5055924 | 0.85 | PARP10 (0.68) | PARP10PARP15PARP4ALDH1A1KMT2A | |
| SCHEMBL1977030 | 0.85 | PARP10 (0.68) | PARP10PARP15PARP4ALDH1A1KMT2A | |
| SCHEMBL1086686 | 0.85 | PARP10 (0.72) | PARP10L3MBTL1GAA | |
| SCHEMBL27987025 | 0.85 | PARP10 (0.68) | PARP10PARP15PARP4ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805163-B1 | 1,1A,5,5A-TETRAHYDRO-3-THIA-CYCLOPROPA[A]PENTALENES: TRICYCLIC THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-10-01 | — | — | EP | claimed |
| EP-3380122-B1 | ANTI-5T4 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES | BYONDIS BV (NL) | 2021-06-02 | — | — | EP | disclosed |