Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.77 |
| ▸ | DPP4 | P27487 | 5/20 | 0.59 |
| ▸ | TACR1 | P25103 | 6/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4689161 | 0.90 | KCNA5 (0.79) | KCNA5KCNH2DPP4TACR1MAPK8 | |
| SCHEMBL4686913 | 0.87 | KCNA5 (1.00) | KCNA5KCNH2DPP4TACR1MAPK8 | |
| SCHEMBL4686242 | 0.86 | KCNA5 (0.81) | KCNA5KCNH2DPP4TACR1MAPK8 | |
| Hydrochloric Acid SCHEMBL295443 | 0.86 | KCNA5 (0.98) | KCNA5KCNH2DPP4TACR1MAPK8 | |
| SCHEMBL4685992 | 0.83 | KCNA5 (0.76) | KCNA5KCNH2DPP4TACR1MAPK8 | |
| SCHEMBL1381998 | 0.83 | KCNA5 (0.76) | KCNA5KCNH2DPP4TACR1MAPK8 | |
| SCHEMBL2904903 | 0.83 | KCNA5 (0.76) | KCNA5KCNH2DPP4TACR1MAPK8 | |
| SCHEMBL3115349 | 0.83 | KCNA5 (0.76) | KCNA5KCNH2DPP4TACR1MAPK8 | |
| SCHEMBL1382996 | 0.83 | KCNA5 (0.76) | KCNA5KCNH2DPP4TACR1MAPK8 | |
| SCHEMBL14303480 | 0.83 | KCNA5 (0.76) | KCNA5KCNH2DPP4TACR1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322619-B1 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2008-01-23 | — | — | EP | disclosed |
| US-6870055-B2 | Isoquinolinone potassium channels inhibitors | MERCK & CO., INC. (US) | 2005-03-22 | — | — | US | disclosed |