SCHEMBL4688495

SCHEMBL4688495

Cc1oc(OC(=O)O)cc1CNc1ccc(-c2ccccc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 9/20 0.57
FFAR1 O14842 5/20 0.44
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
EGFR P00533 1/20 0.42
FFAR4 Q5NUL3 2/20 0.42
PPARG P37231 1/20 0.41
PPARA Q07869 1/20 0.41
HIF1A Q16665 1/20 0.40
ALOX12 P18054 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4691619 0.85 PTGER4 (0.58) PTGER4MEN1KMT2AEGFRPPARG
SCHEMBL3536407 0.82 PTGER4 (0.69) PTGER4FFAR1MEN1KMT2AFFAR4
SCHEMBL3535870 0.81 PTGER4 (0.65) PTGER4FFAR1MEN1KMT2AFFAR4
SCHEMBL4693788 0.78 PTGER4 (0.70) PTGER4
SCHEMBL28756720 0.77 PTGER4 (0.42) PTGER4MEN1KMT2AALOX12
SCHEMBL4688425 0.76 PTGER4 (0.72) PTGER4PPARGPPARA
SCHEMBL3534150 0.73 PTGER4 (1.00) PTGER4ALOX12
SCHEMBL3536678 0.71 PTGER4 (1.00) PTGER4MEN1KMT2A
SCHEMBL4690392 0.71 PTGER4 (0.60) PTGER4
SCHEMBL4694643 0.69 PTGER4 (0.58) PTGER4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1603893-B1 EP4 RECEPTOR ANTAGONISTS ASTERAND UK LTD (GB) 2008-05-21 EP claimed