Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.35 |
| ▸ | GPR183 | P32249 | 2/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4689721 | 1.00 | CNR1 (0.40) | CNR1ENPP2GPR183ESR2ESR1 | |
| SCHEMBL2009444 | 0.88 | GPR183 (0.42) | ENPP2GPR183MAPTKDM4ECCR1 | |
| SCHEMBL2009441 | 0.88 | GPR183 (0.42) | ENPP2GPR183MAPTKDM4ECCR1 | |
| SCHEMBL2003813 | 0.81 | CCR1 (0.44) | ENPP2GPR183CCR1ABCB1 | |
| SCHEMBL2003815 | 0.81 | CCR1 (0.44) | ENPP2GPR183CCR1ABCB1 | |
| SCHEMBL2008868 | 0.77 | CNR1 (0.52) | CNR1ESR2LMNAMEN1KMT2A | |
| SCHEMBL12569193 | 0.77 | CNR1 (0.40) | CNR1MAPTKDM4ELMNAMEN1 | |
| SCHEMBL4687843 | 0.76 | GPR183 (0.41) | ENPP2GPR183MAPTKDM4ECCR1 | |
| SCHEMBL4687847 | 0.76 | GPR183 (0.41) | ENPP2GPR183MAPTKDM4ECCR1 | |
| SCHEMBL2006503 | 0.76 | GPR183 (0.57) | GPR183MAPTKDM4ELMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981504-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV Remynd (BE) | 2008-10-22 | — | — | EP | claimed |
| WO-2007090617-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV REMYND (BE) | 2007-08-16 | — | — | WO | claimed |