Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | EGFR | P00533 | 8/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | PDE5A | O76074 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690253 | 0.94 | MEN1 (0.73) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL4688706 | 0.86 | MEN1 (0.69) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL6181626 | 0.84 | MEN1 (1.00) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL4686940 | 0.79 | MEN1 (0.69) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL4689349 | 0.78 | MEN1 (0.68) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL14001708 | 0.76 | SOS1 (0.73) | ERBB2EPHA2KDREPHB4EGFR | |
| SCHEMBL23142515 | 0.76 | EPHA2 (0.62) | ERBB2EPHA2KDREPHB4EGFR | |
| SCHEMBL4689340 | 0.76 | EPHA2 (0.57) | ERBB2EPHA2KDREPHB4EGFR | |
| SCHEMBL23142519 | 0.76 | EPHA2 (0.62) | ERBB2EPHA2KDREPHB4EGFR | |
| SCHEMBL30250789 | 0.76 | EPHA2 (0.62) | ERBB2EPHA2KDREPHB4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-B1 | GUANIDINE DERIVATIVES OF QUINAZOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |