Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 19/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2945212 | 0.89 | FYN (0.53) | FYN | |
| SCHEMBL2945084 | 0.88 | FYN (0.60) | FYNDYRK3CCNA2CDK2CDK5 | |
| SCHEMBL2945056 | 0.85 | FYN (0.60) | FYNGRK5 | |
| SCHEMBL2944108 | 0.85 | FYN (0.50) | FYNDYRK3CCNA2CDK2CDK5 | |
| SCHEMBL2949133 | 0.85 | FYN (0.53) | FYNGRK5 | |
| SCHEMBL2942431 | 0.83 | FYN (0.60) | FYN | |
| SCHEMBL2943254 | 0.82 | FYN (0.57) | FYNGRK5 | |
| SCHEMBL2947851 | 0.80 | FYN (0.54) | FYNDYRK3CCNA2CDK2CDK5 | |
| SCHEMBL2944904 | 0.79 | FYN (0.52) | FYNDYRK3CCNA2CDK2CDK5 | |
| SCHEMBL2949675 | 0.79 | FYN (0.63) | FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |