Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 18/20 | 0.81 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2945214 | 0.89 | FYN (1.00) | FYNMKNK1 | |
| SCHEMBL2945086 | 0.89 | FYN (0.81) | FYNMKNK1 | |
| SCHEMBL1055715 | 0.86 | FYN (0.81) | FYNMKNK1 | |
| SCHEMBL1053098 | 0.86 | FYN (0.77) | FYNMKNK1KDM4ENPC1RAB9A | |
| SCHEMBL2949134 | 0.85 | FYN (1.00) | FYNMKNK1 | |
| SCHEMBL2944110 | 0.85 | FYN (0.79) | FYNMKNK1 | |
| SCHEMBL1055683 | 0.85 | FYN (1.00) | FYNMKNK1 | |
| SCHEMBL2943456 | 0.84 | FYN (1.00) | FYNMKNK1 | |
| SCHEMBL2942433 | 0.83 | FYN (0.81) | FYN | |
| SCHEMBL30521834 | 0.83 | FYN (1.00) | FYNMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |