Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 9/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.61 |
| ▸ | SRC | P12931 | 4/20 | 0.58 |
| ▸ | SYK | P43405 | 4/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.57 |
| ▸ | HCK | P08631 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4687321 | 0.91 | MAPK14 (0.71) | GSK3AMAPK12SRCSYKMAPK14 | |
| SCHEMBL4687725 | 0.89 | GSK3A (0.66) | GSK3AMAPK12SRCSYKMAPK14 | |
| SCHEMBL6305622 | 0.85 | GSK3A (0.58) | GSK3ASRCSYKMAPK14 | |
| SCHEMBL6545986 | 0.82 | GSK3A (0.60) | GSK3ASRCSYKMAPK14 | |
| SCHEMBL4686400 | 0.82 | GSK3A (0.61) | GSK3AMAPK12SRCSYKMAPK14 | |
| SCHEMBL6299884 | 0.80 | GSK3A (0.66) | GSK3ASRCSYKMAPK14 | |
| SCHEMBL4687325 | 0.80 | MAPK14 (0.77) | GSK3AMAPK12SRCSYKMAPK14 | |
| SCHEMBL16150450 | 0.80 | BRAF (0.67) | GSK3AMAPK12SRCSYKMAPK14 | |
| SCHEMBL4686537 | 0.79 | GSK3A (0.55) | GSK3AMAPK12SRCSYKMAPK14 | |
| SCHEMBL4692696 | 0.79 | MAPK14 (0.67) | GSK3AMAPK12SRCSYKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480973-B1 | 1,4-DISUBSTITUTED BENZOFUSED CYCLOALKYL UREA COMPOUNDS USEFUL IN TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMA (US) | 2008-02-13 | — | — | EP | claimed |
| US-7041669-B2 | 1,4-benzofused urea compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-05-09 | — | — | US | claimed |
| EP-1480973-B1 | 1,4-DISUBSTITUTED BENZOFUSED CYCLOALKYL UREA COMPOUNDS USEFUL IN TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMA (US) | 2008-02-13 | — | — | EP | disclosed |
| US-7041669-B2 | 1,4-benzofused urea compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-05-09 | — | — | US | disclosed |