Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | F10 | P00742 | 4/20 | 0.46 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10149729 | 0.87 | MEN1 (0.46) | F10MAPTALDH1A1NPSR1HTT | |
| SCHEMBL10149225 | 0.85 | IP6K1 (0.53) | LRRK2F10EPHB3MAPTRAB9A | |
| SCHEMBL46907 | 0.81 | F10 (0.51) | LRRK2F10EPHB3MAPTRAB9A | |
| SCHEMBL1697044 | 0.81 | LRRK2 (0.47) | LRRK2F10EPHB3MAPTALDH1A1 | |
| SCHEMBL46914 | 0.75 | LRRK2 (0.43) | LRRK2F10 | |
| SCHEMBL40407 | 0.73 | IP6K1 (0.46) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL46590 | 0.73 | MEN1 (0.46) | MAPTALDH1A1NPSR1HTTSRC | |
| SCHEMBL40848 | 0.71 | F10 (0.50) | LRRK2F10MAPTRAB9ANPC1 | |
| SCHEMBL1696925 | 0.71 | HPGD (0.49) | MAPTSMN1; SMN2ALDH1A1L3MBTL1HTT | |
| SCHEMBL40465 | 0.70 | RXFP1 (0.52) | LRRK2F10MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |