Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 8/20 | 0.77 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.65 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.65 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.65 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.63 |
| ▸ | CIT | O14578 | 1/20 | 0.63 |
| ▸ | MUSK | O15146 | 1/20 | 0.63 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.63 |
| ▸ | STK10 | O94804 | 1/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.63 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.63 |
| ▸ | ABL1 | P00519 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.63 |
| ▸ | RAF1 | P04049 | 1/20 | 0.63 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.63 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.63 |
| ▸ | PRKCB | P05771 | 1/20 | 0.63 |
| ▸ | LCK | P06239 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4686576 | 0.93 | TNF (0.77) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4689610 | 0.92 | TNF (0.75) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4687345 | 0.91 | TNF (0.76) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4686520 | 0.90 | TNF (0.76) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4686570 | 0.89 | TNF (0.77) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4689855 | 0.89 | TNF (0.79) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4688973 | 0.88 | MAPK14 (0.73) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4689526 | 0.88 | TNF (0.78) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4690591 | 0.87 | TNF (0.74) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4687541 | 0.87 | TNF (0.76) | TNFMAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480973-B1 | 1,4-DISUBSTITUTED BENZOFUSED CYCLOALKYL UREA COMPOUNDS USEFUL IN TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMA (US) | 2008-02-13 | — | — | EP | claimed |
| US-7041669-B2 | 1,4-benzofused urea compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-05-09 | — | — | US | claimed |
| EP-1480973-B1 | 1,4-DISUBSTITUTED BENZOFUSED CYCLOALKYL UREA COMPOUNDS USEFUL IN TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMA (US) | 2008-02-13 | — | — | EP | disclosed |
| US-7041669-B2 | 1,4-benzofused urea compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-05-09 | — | — | US | disclosed |
| EP-1480973-A1 | 1,4-DISUBSTITUTED BENZOFUSED CYCLOALKYL UREA COMPOUNDS USEFUL IN TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003072569-A1 | 1,4-DISUBSTITUTED BENZOFUSED CYCLOALKYL UREA COMPOUNDS USEFUL IN TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-09-04 | — | — | WO | disclosed |