Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 12/20 | 0.74 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.57 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20485733 | 0.85 | FYN (1.00) | FYNMKNK1 | |
| SCHEMBL2947844 | 0.84 | IKBKB (0.58) | FYNMKNK1IKBKBAAK1 | |
| SCHEMBL2948850 | 0.84 | MKNK1 (0.67) | FYNMKNK1IKBKBPIM1 | |
| SCHEMBL2948860 | 0.83 | FYN (0.71) | FYNMKNK1IKBKBAAK1PIM1 | |
| SCHEMBL3036460 | 0.82 | FYN (0.76) | FYNMKNK1IKBKB | |
| SCHEMBL2950410 | 0.79 | FYN (0.78) | FYNMKNK1 | |
| SCHEMBL2949007 | 0.78 | FYN (0.77) | FYNMKNK1IKBKBAAK1 | |
| SCHEMBL13234778 | 0.78 | MKNK1 (0.63) | FYNMKNK1IKBKBPIM1 | |
| SCHEMBL2946476 | 0.77 | FYN (0.60) | FYNMKNK1PIM1 | |
| SCHEMBL1053471 | 0.77 | FYN (0.82) | FYNMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |