Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 9/20 | 0.65 |
| ▸ | PIM1 | P11309 | 6/20 | 0.63 |
| ▸ | FYN | P06241 | 4/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4325978 | 0.90 | FYN (0.57) | RETPIM1FYN | |
| SCHEMBL4332422 | 0.87 | PIM1 (0.70) | RETPIM1FYNPIM2 | |
| SCHEMBL4594999 | 0.86 | PIM1 (0.58) | RETPIM1FYNPIM2 | |
| SCHEMBL4334079 | 0.86 | PIM1 (0.58) | RETPIM1FYNPIM2 | |
| SCHEMBL13990605 | 0.86 | PIM1 (0.56) | RETPIM1FYNKDRPIM2 | |
| SCHEMBL4569917 | 0.84 | FYN (0.74) | RETPIM1FYN | |
| SCHEMBL4337401 | 0.84 | PIM1 (0.56) | RETPIM1FYNKDRPIM2 | |
| SCHEMBL4340381 | 0.83 | PIM1 (0.55) | RETPIM1FYNPIM2 | |
| SCHEMBL4344889 | 0.83 | RET (0.62) | RETPIM1FYN | |
| SCHEMBL4335120 | 0.83 | FYN (0.76) | RETPIM1FYNKDRPIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |