SCHEMBL4691880

SCHEMBL4691880

C[C@H](c1ccc(Cl)cc1)[C@H](CNC(=O)C(C)(C)Oc1cc(F)cc(F)c1)c1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 20/20 0.67
CNR2 P34972 12/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2656390 1.00 CNR1 (0.67) CNR1CNR2
SCHEMBL4689482 0.96 CNR1 (0.62) CNR1CNR2
SCHEMBL4688560 0.96 CNR1 (0.60) CNR1CNR2
SCHEMBL4688265 0.93 CNR1 (0.67) CNR1CNR2
SCHEMBL4693234 0.93 CNR1 (0.56) CNR1CNR2
SCHEMBL4688366 0.92 CNR1 (0.59) CNR1CNR2
SCHEMBL4691557 0.92 CNR1 (0.65) CNR1CNR2
SCHEMBL4694395 0.92 CNR1 (0.65) CNR1CNR2
SCHEMBL4692000 0.92 CNR1 (0.65) CNR1CNR2
SCHEMBL2652787 0.92 CNR1 (0.56) CNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1496838-A4 SUBSTITUTED AMIDES MERCK & CO INC (US) 2008-07-02 EP disclosed
EP-1496838-A2 SUBSTITUTED AMIDES Merck & Co., Inc. (US) 2005-01-19 EP disclosed
WO-2003077847-A2 SUBSTITUTED AMIDES MERCK & CO., INC. (US) 2003-09-25 WO disclosed