Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 11/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.51 |
| ▸ | IKBKB | O14920 | 2/20 | 0.50 |
| ▸ | FYN | P06241 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1055463 | 0.89 | FYN (0.61) | PIM1KCNH2MKNK1IKBKBFYN | |
| SCHEMBL1053320 | 0.80 | FYN (0.62) | PIM1KCNH2MKNK1IKBKBFYN | |
| SCHEMBL3042095 | 0.78 | FYN (0.63) | PIM1KCNH2MKNK1IKBKBFYN | |
| SCHEMBL3042098 | 0.78 | FYN (0.63) | PIM1KCNH2MKNK1IKBKBFYN | |
| SCHEMBL3036707 | 0.77 | PIM1 (0.66) | PIM1KCNH2MKNK1IKBKBFYN | |
| SCHEMBL3036703 | 0.77 | PIM1 (0.66) | PIM1KCNH2MKNK1IKBKBFYN | |
| SCHEMBL3041613 | 0.77 | PIM1 (0.76) | PIM1KCNH2MKNK1IKBKBFYN | |
| SCHEMBL3041629 | 0.77 | PIM1 (0.76) | PIM1KCNH2MKNK1IKBKBFYN | |
| SCHEMBL19467148 | 0.77 | FYN (0.62) | PIM1MKNK1IKBKBFYN | |
| SCHEMBL15254599 | 0.77 | MKNK1 (0.57) | MKNK1IKBKBFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |