Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 10/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.66 |
| ▸ | IKBKB | O14920 | 1/20 | 0.58 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.57 |
| ▸ | FYN | P06241 | 5/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | MET | P08581 | 1/20 | 0.56 |
| ▸ | ROS1 | P08922 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | FGR | P09769 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1055831 | 0.90 | MKNK1 (0.71) | PIM1KCNH2IKBKBMKNK1FYN | |
| SCHEMBL103576 | 0.88 | PIM1 (1.00) | PIM1KCNH2FYNNTRK1NTRK3 | |
| SCHEMBL102864 | 0.88 | PIM1 (1.00) | PIM1KCNH2FYNNTRK1NTRK3 | |
| SCHEMBL138888 | 0.88 | PIM1 (1.00) | PIM1KCNH2FYNNTRK1NTRK3 | |
| SCHEMBL1053959 | 0.88 | FYN (0.74) | PIM1KCNH2MKNK1FYNJAK2 | |
| SCHEMBL3027667 | 0.87 | PIM1 (0.70) | PIM1KCNH2IKBKBMKNK1FYN | |
| SCHEMBL3027664 | 0.87 | PIM1 (0.70) | PIM1KCNH2IKBKBMKNK1FYN | |
| SCHEMBL3038028 | 0.86 | PIM1 (0.72) | PIM1KCNH2IKBKBMKNK1FYN | |
| SCHEMBL3038023 | 0.86 | PIM1 (0.72) | PIM1KCNH2IKBKBMKNK1FYN | |
| SCHEMBL3037594 | 0.86 | PIM1 (0.67) | PIM1KCNH2IKBKBMKNK1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |