Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | ANPEP | P15144 | 3/20 | 0.42 |
| ▸ | LAP3 | P28838 | 2/20 | 0.42 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.42 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | CTSC | P53634 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4688760 | 0.88 | CSNK1E (0.49) | CSNK1EF2ANPEPLAP3RNPEP | |
| SCHEMBL5930069 | 0.84 | CSNK1E (0.57) | CSNK1EF2ANPEPLAP3RNPEP | |
| SCHEMBL3355611 | 0.83 | CSNK1E (0.56) | CSNK1EF2ANPEPLAP3RNPEP | |
| SCHEMBL7300383 | 0.83 | CSNK1E (0.54) | CSNK1EF2ANPEPLAP3RNPEP | |
| Hydrochloric Acid SCHEMBL4692753 | 0.82 | CSNK1E (0.56) | CSNK1EF2ANPEPLAP3RNPEP | |
| SCHEMBL3469029 | 0.82 | CSNK1E (0.49) | CSNK1EF2ANPEPLAP3RNPEP | |
| SCHEMBL3469148 | 0.82 | CSNK1E (0.44) | CSNK1EF2ANPEPLAP3RNPEP | |
| Hydrochloric Acid SCHEMBL5218959 | 0.82 | CSNK1E (0.55) | CSNK1EF2ANPEPLAP3RNPEP | |
| Hydrochloric Acid SCHEMBL7310009 | 0.81 | CSNK1E (0.53) | CSNK1EF2ANPEPLAP3RNPEP | |
| SCHEMBL3355145 | 0.81 | CSNK1E (0.62) | CSNK1EF2ANPEPLAP3RNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692143-B1 | TRICYCLIC INDOLE HYDROXYETHYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2008-11-12 | — | — | EP | disclosed |