Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 20/20 | 0.70 |
| ▸ | CX3CR1 | P49238 | 3/20 | 0.66 |
| ▸ | HTR1B | P28222 | 1/20 | 0.59 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.56 |
| ▸ | CCR7 | P32248 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2905264 | 0.99 | CXCR2 (0.71) | CXCR2CX3CR1HTR1BCXCR1CCR7 | |
| SCHEMBL4693395 | 0.98 | CXCR2 (0.70) | CXCR2CX3CR1HTR1BCXCR1CCR7 | |
| SCHEMBL842340 | 0.92 | CXCR2 (0.71) | CXCR2CX3CR1HTR1BCXCR1CCR7 | |
| SCHEMBL13140053 | 0.90 | CXCR2 (0.70) | CXCR2CX3CR1HTR1BCXCR1CCR7 | |
| SCHEMBL841616 | 0.84 | CXCR2 (0.98) | CXCR2CX3CR1HTR1B | |
| SCHEMBL842296 | 0.83 | CXCR2 (0.72) | CXCR2CX3CR1HTR1BCXCR1CCR7 | |
| SCHEMBL841899 | 0.83 | CXCR2 (1.00) | CXCR2CX3CR1HTR1B | |
| SCHEMBL842524 | 0.82 | CXCR2 (0.86) | CXCR2CX3CR1HTR1B | |
| SCHEMBL841617 | 0.82 | CXCR2 (0.98) | CXCR2CX3CR1HTR1B | |
| SCHEMBL4711342 | 0.81 | CXCR2 (0.83) | CXCR2CX3CR1HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543013-B1 | 5-[[(2,3-Difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one monosodium salt as CXCR2 antagonist | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | EP | disclosed |