Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 11/20 | 0.60 |
| ▸ | JAK2 | O60674 | 8/20 | 0.50 |
| ▸ | JAK3 | P52333 | 7/20 | 0.50 |
| ▸ | JAK1 | P23458 | 4/20 | 0.48 |
| ▸ | TYK2 | P29597 | 4/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 2/20 | 0.48 |
| ▸ | PAK4 | O96013 | 2/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | FER | P16591 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | STAT5A | P42229 | 1/20 | 0.48 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.48 |
| ▸ | STK4 | Q13043 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694101 | 1.00 | NTRK1 (0.60) | NTRK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL4696343 | 0.86 | JAK2 (0.50) | NTRK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL4696346 | 0.86 | JAK2 (0.50) | NTRK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL4072344 | 0.85 | NTRK1 (0.80) | NTRK1 | |
| SCHEMBL4697160 | 0.84 | NTRK1 (0.55) | NTRK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL4697154 | 0.84 | NTRK1 (0.55) | NTRK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL4618549 | 0.83 | NTRK1 (0.67) | NTRK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL2568696 | 0.83 | NTRK1 (0.52) | NTRK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL3137642 | 0.82 | NTRK1 (0.50) | NTRK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL3137662 | 0.82 | NTRK1 (0.50) | NTRK1JAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |