Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 16/20 | 0.82 |
| ▸ | IGF1R | P08069 | 4/20 | 0.65 |
| ▸ | JAK2 | O60674 | 2/20 | 0.64 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2634279 | 1.00 | NTRK1 (0.82) | NTRK1IGF1RJAK2JAK3 | |
| SCHEMBL4160441 | 0.89 | NTRK1 (0.82) | NTRK1IGF1RJAK2JAK3 | |
| SCHEMBL4144686 | 0.89 | NTRK1 (1.00) | NTRK1IGF1R | |
| SCHEMBL4072344 | 0.87 | NTRK1 (0.80) | NTRK1IGF1R | |
| SCHEMBL3338305 | 0.86 | NTRK1 (0.78) | NTRK1IGF1RJAK2JAK3 | |
| SCHEMBL2634646 | 0.85 | NTRK1 (0.72) | NTRK1IGF1RJAK2JAK3 | |
| SCHEMBL2634640 | 0.85 | NTRK1 (0.77) | NTRK1IGF1RJAK2JAK3 | |
| SCHEMBL4070045 | 0.84 | NTRK1 (0.75) | NTRK1IGF1RJAK2JAK3 | |
| SCHEMBL22535688 | 0.83 | NTRK1 (0.76) | NTRK1IGF1RJAK2JAK3 | |
| SCHEMBL4696037 | 0.83 | NTRK1 (0.85) | NTRK1IGF1RJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |