Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 1/20 | 0.69 |
| ▸ | PIM1 | P11309 | 14/20 | 0.66 |
| ▸ | PIM2 | Q9P1W9 | 12/20 | 0.62 |
| ▸ | FLT3 | P36888 | 4/20 | 0.59 |
| ▸ | FYN | P06241 | 4/20 | 0.52 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.49 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4338906 | 0.88 | PIK3CG (0.78) | PIK3CGPIM1PIM2FLT3FYN | |
| SCHEMBL1424084 | 0.85 | PIK3CG (0.71) | PIK3CGPIM1PIM2FLT3FYN | |
| SCHEMBL1424085 | 0.85 | PIK3CG (0.71) | PIK3CGPIM1PIM2FLT3FYN | |
| SCHEMBL4328408 | 0.83 | PIK3CG (0.72) | PIK3CGPIM1PIM2FLT3 | |
| SCHEMBL4340311 | 0.83 | PIK3CG (0.71) | PIK3CGPIM1PIM2FLT3FYN | |
| SCHEMBL4692526 | 0.83 | PIM1 (0.73) | PIK3CGPIM1PIM2FLT3 | |
| SCHEMBL4342776 | 0.82 | PIK3CG (1.00) | PIK3CGPIM1PIM2FLT3FYN | |
| SCHEMBL4339100 | 0.82 | PIM1 (0.72) | PIK3CGPIM1PIM2FLT3 | |
| SCHEMBL4332530 | 0.82 | PIM1 (0.72) | PIK3CGPIM1PIM2FLT3 | |
| SCHEMBL4333807 | 0.81 | PIM1 (0.68) | PIK3CGPIM1PIM2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |