Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 14/20 | 0.79 |
| ▸ | DYRK3 | O43781 | 6/20 | 0.78 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.78 |
| ▸ | CDK9 | P50750 | 6/20 | 0.78 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.78 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.78 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.78 |
| ▸ | DYRK2 | Q92630 | 6/20 | 0.78 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.78 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.78 |
| ▸ | CDK2 | P24941 | 5/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694447 | 1.00 | FYN (0.79) | FYNDYRK3CCNT1CDK9CDK5 | |
| SCHEMBL18613468 | 0.88 | FYN (1.00) | FYNDYRK3CCNT1CDK9CDK5 | |
| SCHEMBL20485793 | 0.88 | FYN (1.00) | FYNDYRK3CCNT1CDK9CDK5 | |
| SCHEMBL1055975 | 0.86 | FYN (0.81) | FYNDYRK3CCNT1CDK9CDK5 | |
| SCHEMBL1055974 | 0.86 | FYN (0.81) | FYNDYRK3CCNT1CDK9CDK5 | |
| SCHEMBL2947149 | 0.85 | FYN (0.79) | FYNDYRK3CCNT1CDK9CDK5 | |
| SCHEMBL16332008 | 0.85 | FYN (1.00) | FYNDYRK3CCNT1CDK9CDK5 | |
| SCHEMBL20485848 | 0.85 | FYN (1.00) | FYNDYRK3CCNT1CDK9CDK5 | |
| SCHEMBL1055088 | 0.85 | FYN (0.79) | FYNDYRK3CCNT1CDK9CDK5 | |
| SCHEMBL2947145 | 0.85 | FYN (0.79) | FYNDYRK3CCNT1CDK9CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |