Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.61 |
| ▸ | NCOR2 | Q9Y618 | 5/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL469454 | 0.98 | SMN1; SMN2 (0.67) | SMN1; SMN2RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL469451 | 0.95 | SMN1; SMN2 (0.67) | SMN1; SMN2RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL469448 | 0.88 | SMN1; SMN2 (0.71) | SMN1; SMN2RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL8363038 | 0.87 | HDAC1 (0.72) | SMN1; SMN2RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL4138124 | 0.86 | CETP (0.67) | SMN1; SMN2RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL21665202 | 0.83 | HTT (0.60) | MAPTALDH1A1GAAHDAC3HDAC1 | |
| SCHEMBL27918779 | 0.82 | CETP (0.65) | SMN1; SMN2RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL7717024 | 0.82 | HDAC3 (0.61) | SMN1; SMN2RAB9ANPC1ALDH1A1GAA | |
| SCHEMBL7717055 | 0.82 | HDAC3 (0.61) | SMN1; SMN2RAB9ANPC1ALDH1A1GAA | |
| SCHEMBL7719067 | 0.82 | HDAC3 (0.61) | SMN1; SMN2RAB9ANPC1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9527805-B2 | Small molecules as epigenetic modulators of lysine-specific demethylase 1 and methods of treating disorders | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-12-27 | — | — | US | disclosed |
| US-20140011857-A1 | SMALL MOLECULES AS EPIGENETIC MODULATORS OF LYSINE-SPECIFIC DEMETHYLASE 1 AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-01-09 | — | — | US | disclosed |
| WO-2012034116-A2 | SMALL MOLECULES AS EPIGENETIC MODULATORS OF LYSINE-SPECIFIC DEMETHYLASE 1 AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140011857-A1 | SMALL MOLECULES AS EPIGENETIC MODULATORS OF LYSINE-SPECIFIC DEMETHYLASE 1 AND METHODS OF TREATING DISORDERS | KDM1B, DOT1L, EHMT1 | SMN1; SMN2 480/4885RAB9A 2964/4885NPC1 1172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.