Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 1/20 | 0.58 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | LAP3 | P28838 | 3/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.43 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039327 | 0.96 | CSNK1E (0.57) | CSNK1EBCHESIGMAR1MEN1KMT2A | |
| SCHEMBL11590730 | 0.82 | CSNK1E (0.76) | CSNK1ESIGMAR1LAP3ANPEPRNPEP | |
| SCHEMBL3352849 | 0.82 | CSNK1E (0.47) | CSNK1EBCHEMEN1KMT2AF2 | |
| SCHEMBL5382881 | 0.81 | CSNK1E (0.53) | CSNK1EBCHESIGMAR1F2LAP3 | |
| SCHEMBL5431496 | 0.81 | CSNK1E (0.47) | CSNK1EBCHESIGMAR1F2 | |
| SCHEMBL5426362 | 0.81 | CSNK1E (0.47) | CSNK1EBCHESIGMAR1F2 | |
| SCHEMBL5222215 | 0.81 | CSNK1E (0.52) | CSNK1EBCHESIGMAR1F2LAP3 | |
| SCHEMBL4689540 | 0.81 | CSNK1E (0.52) | CSNK1EBCHESIGMAR1F2LAP3 | |
| SCHEMBL4693550 | 0.81 | CSNK1E (0.52) | CSNK1EBCHESIGMAR1F2LAP3 | |
| Hydrochloric Acid SCHEMBL5224300 | 0.80 | CSNK1E (0.51) | CSNK1EBCHESIGMAR1F2LAP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692143-B1 | TRICYCLIC INDOLE HYDROXYETHYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2008-11-12 | — | — | EP | disclosed |