Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.68 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | LCAT | P04180 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3867511 | 1.00 | HRH3 (0.68) | HRH3CHRM4SLC6A9CYP3A4PIK3CD | |
| Hydrochloric Acid SCHEMBL4693269 | 0.99 | HRH3 (0.67) | HRH3CHRM4SLC6A9CYP3A4PIK3CD | |
| SCHEMBL4666727 | 0.96 | HRH3 (0.62) | HRH3CHRM4SLC6A9CYP3A4PIK3CD | |
| SCHEMBL13683681 | 0.87 | HRH3 (0.52) | HRH3CHRM4SLC6A9PIK3CD | |
| Hydrochloric Acid SCHEMBL3861514 | 0.86 | HRH3 (0.52) | HRH3CHRM4SLC6A9PIK3CD | |
| SCHEMBL3867307 | 0.85 | HRH3 (0.48) | HRH3SLC6A9 | |
| SCHEMBL4688718 | 0.85 | HRH3 (0.48) | HRH3SLC6A9 | |
| SCHEMBL3859666 | 0.84 | HRH3 (0.92) | HRH3CHRM4SLC6A9CYP3A4MMP2 | |
| SCHEMBL4691427 | 0.84 | HRH3 (0.48) | HRH3SLC6A9LCAT | |
| Hydrochloric Acid SCHEMBL3858798 | 0.84 | HRH3 (0.48) | HRH3SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615909-B1 | PIPERAZINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISEASES | GLAXO GROUP LTD (GB) | 2008-07-23 | — | — | EP | claimed |