Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 10/20 | 0.53 |
| ▸ | RET | P07949 | 9/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4337317 | 0.89 | RET (0.61) | PIM1RETPIM2 | |
| SCHEMBL4331218 | 0.81 | RET (0.61) | PIM1RET | |
| SCHEMBL4558405 | 0.78 | FYN (0.56) | PIM1RET | |
| SCHEMBL4340361 | 0.76 | FYN (0.46) | PIM1RETPIM2 | |
| SCHEMBL4335443 | 0.76 | RET (0.53) | PIM1RETPIM2 | |
| SCHEMBL4332790 | 0.75 | FYN (0.45) | PIM1RET | |
| SCHEMBL4337307 | 0.73 | RET (0.67) | PIM1RETPIM2 | |
| SCHEMBL4331224 | 0.72 | PIM1 (0.74) | PIM1RETPIM2 | |
| SCHEMBL4693637 | 0.72 | RET (0.73) | PIM1RETPIM2 | |
| SCHEMBL4331386 | 0.72 | RET (0.62) | PIM1RETPIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |