SCHEMBL4695230

SCHEMBL4695230

Cn1ncc(Cl)c1-c1cc(NC(=O)Oc2ccc(Cl)s2)ccc1OCCN1CCOCC1

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 20/20 0.72
HTR2C P28335 16/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1166501 0.88 HTR2A (0.73) HTR2AHTR2C
SCHEMBL16530995 0.86 HTR2A (0.64) HTR2AHTR2C
SCHEMBL1865155 0.86 HTR2A (0.82) HTR2AHTR2C
SCHEMBL1165507 0.85 HTR2A (0.77) HTR2AHTR2C
SCHEMBL3948057 0.84 HTR2A (0.80) HTR2AHTR2C
SCHEMBL1863541 0.84 HTR2A (0.74) HTR2AHTR2C
SCHEMBL1165385 0.84 HTR2A (1.00) HTR2AHTR2C
SCHEMBL1166012 0.83 HTR2A (0.89) HTR2AHTR2C
SCHEMBL4036084 0.83 HTR2A (0.80) HTR2AHTR2C
SCHEMBL1165422 0.83 HTR2A (0.89) HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1833799-B1 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT-2a SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARM INC (US) 2008-09-10 EP claimed