Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | UBE2N | P61088 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.54 |
| ▸ | TEK | Q02763 | 9/20 | 0.50 |
| ▸ | KDR | P35968 | 7/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751375 | 0.89 | KDM4E (0.57) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL12607050 | 0.89 | KDM4E (0.57) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL12607049 | 0.89 | KDM4E (0.57) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL12607165 | 0.86 | KDM4E (0.52) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL12607159 | 0.86 | KDM4E (0.52) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4748283 | 0.85 | KDM4E (0.59) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4697464 | 0.84 | KDM4E (0.56) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL14467289 | 0.84 | KDM4E (0.60) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL12607051 | 0.84 | KDM4E (0.60) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL12607062 | 0.83 | TNK2 (0.50) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966218-A1 | NOVEL, CYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | Bayer HealthCare AG (DE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007079861-A1 | NOVEL, CYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2007-07-19 | — | — | WO | disclosed |