Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.35 |
| ▸ | TACR1 | P25103 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14573729 | 1.00 | TSHR (0.37) | TSHRPTGER4TACR1MEN1KMT2A | |
| SCHEMBL14573798 | 0.92 | TACR1 (0.31) | TSHRPTGER4TACR1MAPTKDM4E | |
| SCHEMBL14573822 | 0.87 | TSHR (0.41) | TSHRPTGER4TACR1MEN1KMT2A | |
| SCHEMBL4694444 | 0.86 | TSHR (0.41) | TSHRPTGER4TACR1MEN1KMT2A | |
| SCHEMBL14573710 | 0.86 | MAPK1 (0.32) | TACR1MAPTKDM4EALDH1A1CYP1A2 | |
| SCHEMBL4693897 | 0.86 | MAPK1 (0.32) | TACR1MAPTKDM4EALDH1A1CYP1A2 | |
| SCHEMBL4693900 | 0.86 | MAPK1 (0.32) | TACR1MAPTKDM4EALDH1A1CYP1A2 | |
| SCHEMBL4693904 | 0.86 | MAPK1 (0.32) | TACR1MAPTKDM4EALDH1A1CYP1A2 | |
| SCHEMBL14573824 | 0.84 | PTGER4 (0.36) | TSHRPTGER4TACR1L3MBTL1 | |
| SCHEMBL13943887 | 0.78 | KDM4E (0.40) | PTGER4TACR1MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888581-A2 | HIV-INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2008-02-20 | — | — | EP | disclosed |
| US-20070072831-A1 | Integrase inhibitor compounds | GILEAD SCIENCES, INC. | 2007-03-29 | — | — | US | disclosed |
| WO-2006125048-A2 | HIV-INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072831-A1 | Integrase inhibitor compounds | TYMP, CDKN1A, PAICS | TSHR 4773/4885PTGER4 3914/4885TACR1 4662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.