Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 7/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8913592 | 1.00 | EPHX1 (0.50) | EPHX1CES2CES1CYP1A2KMT2A | |
| Bicarbonate SCHEMBL17847302 | 1.00 | EPHX1 (0.50) | EPHX1CES2CES1CYP1A2KMT2A | |
| Methylcyclopentane SCHEMBL8746944 | 0.97 | EPHX1 (0.46) | EPHX1CES2CES1CYP1A2KMT2A | |
| Acetic Acid SCHEMBL4087167 | 0.91 | EPHX1 (0.48) | EPHX1CES2CES1CYP1A2KMT2A | |
| Acetic Acid SCHEMBL938460 | 0.91 | EPHX1 (0.48) | EPHX1CES2CES1CYP1A2KMT2A | |
| Acetic Acid SCHEMBL4093239 | 0.91 | EPHX1 (0.48) | EPHX1CES2CES1CYP1A2KMT2A | |
| Hydrogen Peroxide SCHEMBL2220600 | 0.90 | — | — | |
| Carbamic Acid SCHEMBL7466501 | 0.88 | EPHX1 (0.46) | EPHX1CES2CES1CYP1A2KMT2A | |
| SCHEMBL5728127 | 0.88 | EPHX1 (0.46) | EPHX1CES2CES1CYP1A2KMT2A | |
| SCHEMBL8964234 | 0.88 | EPHX1 (0.46) | EPHX1CES2CES1CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3694900-B1 | NON-AQUEOUS CROSSLINKABLE COMPOSITION | ALLNEX NETHERLANDS BV (NL) | 2024-01-24 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1589031-B1 | Production of polyketides and other natural products | BIOTICA TECH LTD (GB) | 2007-08-15 | — | — | EP | claimed |
| CN-116239826-A | Starch-fatty alcohol complex and preparation method thereof | 中国农业大学 | 2023-06-09 | — | — | CN | disclosed |
| EP-1694665-A2 | SUBSTITUTED THIOPHENES | AiCuris GmbH & Co. KG (DE) | 2006-08-30 | — | — | EP | disclosed |
| WO-2006072348-A2 | ALKINYL-SUBSTITUTED THIOPHENES | AICURIS GMBH & CO. KG (DE) | 2006-07-13 | — | — | WO | disclosed |
| WO-2006072347-A2 | ALKINYL-SUBSTITUTED THIOPHENES | AICURIS GMBH & CO. KG (DE) | 2006-07-13 | — | — | WO | disclosed |
| WO-2005063734-A2 | SUBSTITUTED THIOPHENES | AICURIS GMBH & CO. KG (DE) | 2005-07-14 | — | — | WO | disclosed |
| WO-2000027826-A1 | NOVEL PYRIMIDINES, THE PRODUCTION THEREOF AND THEIR USE | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-05-18 | — | — | WO | disclosed |
| EP-0816392-A2 | Hydrocarbon resins modified with fatty acid esters | Vianova Resins GmbH (DE) | 1998-01-07 | — | — | EP | disclosed |
| EP-0508370-B1 | Condensed diazepinones, process for their preparation and compositions containing them for the treatment of the central nervous system and to enhance cerebral perfusion | THOMAE GMBH DR K (DE) | 1996-07-03 | — | — | EP | disclosed |
| EP-0168608-A2 | Substituted carboxylic-acid anilides | BAYER AG (DE) | 1986-01-22 | — | — | EP | disclosed |
| EP-0089011-B1 | PROCESS FOR THE PREPARATION OF 5-OXONITRILES | Degussa Aktiengesellschaft (DE) | 1985-07-10 | — | — | EP | disclosed |
| EP-0126934-A2 | Process for the preparation of 1,1-disubstituted thioureas | BASF Aktiengesellschaft (DE) | 1984-12-05 | — | — | EP | disclosed |
| EP-0089011-A1 | Process for the preparation of 5-oxonitriles | Degussa Aktiengesellschaft (DE) | 1983-09-21 | — | — | EP | disclosed |
| EP-0007508-B1 | ACYLPHOSPHINOXIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE | BASF Aktiengesellschaft (DE) | 1983-06-01 | — | — | EP | disclosed |
| EP-0053307-A1 | Imidazole and triazole pesticides | CELAMERCK GmbH & Co. KG (DE) | 1982-06-09 | — | — | EP | disclosed |
| EP-0007086-B1 | LIGHT-CURABLE MOULDING, IMPREGNATING AND COATING COMPOSITIONS AND SHAPED ARTICLES PREPARED THEREFROM | BASF Aktiengesellschaft (DE) | 1982-02-10 | — | — | EP | disclosed |
| EP-0007508-A2 | Acylphosphinoxide compounds, their preparation and their use | BASF Aktiengesellschaft (DE) | 1980-02-06 | — | — | EP | disclosed |
| EP-0007086-A1 | Light-curable moulding, impregnating and coating compositions and shaped articles prepared therefrom | BASF Aktiengesellschaft (DE) | 1980-01-23 | — | — | EP | disclosed |