Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 4/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | COMT | P21964 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CALCA | P06881 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5649171 | 0.76 | KMT2A (0.40) | KDM4EL3MBTL1TACR1RAB9AKMT2A | |
| SCHEMBL4695601 | 0.73 | TDP1 (0.32) | PARP1LMNATDP1CNR2EGLN1 | |
| SCHEMBL14573843 | 0.72 | COMT (0.38) | KDM4ECOMTKMT2AMEN1HSP90AA1 | |
| SCHEMBL4690010 | 0.70 | KDM4E (0.40) | KDM4EL3MBTL1TACR1COMTRAB9A | |
| SCHEMBL4904131 | 0.70 | CNR2 (0.37) | KDM4EL3MBTL1TACR1RAB9AKMT2A | |
| SCHEMBL4694444 | 0.70 | TSHR (0.41) | KDM4EL3MBTL1TACR1RAB9AKMT2A | |
| SCHEMBL5650550 | 0.70 | KDM4E (0.41) | KDM4EL3MBTL1TACR1RAB9AKMT2A | |
| SCHEMBL14573817 | 0.70 | TACR1 (0.37) | KDM4EL3MBTL1TACR1RAB9AKMT2A | |
| SCHEMBL4162799 | 0.69 | KDM4E (0.39) | KDM4EL3MBTL1COMTRAB9AKMT2A | |
| SCHEMBL4750436 | 0.69 | KDM4E (0.39) | KDM4EL3MBTL1TACR1COMTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888581-A2 | HIV-INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006125048-A2 | HIV-INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2006-11-23 | — | — | WO | disclosed |