Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MDM4 | O15151 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.43 |
| ▸ | CETP | P11597 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL469618 | 0.82 | KDM1A (1.00) | KDM1AALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL10137740 | 0.82 | KDM1A (0.71) | KDM1AALDH1A1POLB | |
| SCHEMBL10138046 | 0.81 | KDM1A (0.66) | KDM1AALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL10138056 | 0.81 | KDM1A (0.69) | KDM1AALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL469531 | 0.81 | KDM1A (0.69) | KDM1AALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL469623 | 0.81 | KDM1A (0.69) | KDM1AALDH1A1CYP1A2CYP3A4POLB | |
| SCHEMBL10138047 | 0.81 | KDM1A (0.69) | KDM1AALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL469617 | 0.80 | KDM1A (0.64) | KDM1AALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL469622 | 0.79 | KDM1A (0.68) | KDM1AALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL469609 | 0.78 | KDM1A (0.66) | KDM1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9527805-B2 | Small molecules as epigenetic modulators of lysine-specific demethylase 1 and methods of treating disorders | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-12-27 | — | — | US | disclosed |
| US-20140011857-A1 | SMALL MOLECULES AS EPIGENETIC MODULATORS OF LYSINE-SPECIFIC DEMETHYLASE 1 AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-01-09 | — | — | US | disclosed |
| WO-2012034116-A2 | SMALL MOLECULES AS EPIGENETIC MODULATORS OF LYSINE-SPECIFIC DEMETHYLASE 1 AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140011857-A1 | SMALL MOLECULES AS EPIGENETIC MODULATORS OF LYSINE-SPECIFIC DEMETHYLASE 1 AND METHODS OF TREATING DISORDERS | KDM1B, DOT1L, EHMT1 | KDM1A 6/4885ALDH1A1 1115/4885CYP1A2 3999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.