Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.61 |
| ▸ | BRAF | P15056 | 4/20 | 0.52 |
| ▸ | RAF1 | P04049 | 3/20 | 0.52 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | LYN | P07948 | 2/20 | 0.52 |
| ▸ | FRK | P42685 | 2/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.52 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.52 |
| ▸ | MTOR | P42345 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ESYT2 | A0FGR8 | 1/20 | 0.52 |
| ▸ | PLEKHG3 | A1L390 | 1/20 | 0.52 |
| ▸ | NBAS | A2RRP1 | 1/20 | 0.52 |
| ▸ | CNOT1 | A5YKK6 | 1/20 | 0.52 |
| ▸ | TBKBP1 | A7MCY6 | 1/20 | 0.52 |
| ▸ | MYO1G | B0I1T2 | 1/20 | 0.52 |
| ▸ | AGPS | O00116 | 1/20 | 0.52 |
| ▸ | MYO1F | O00160 | 1/20 | 0.52 |
| ▸ | SNAP23 | O00161 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698765 | 0.88 | BRAF (0.61) | MAPK14BRAFRAF1PIP4K2ALCK | |
| SCHEMBL4698202 | 0.86 | MAPK14 (0.63) | MAPK14BRAFRAF1PIP4K2ALCK | |
| SCHEMBL4698956 | 0.85 | MAPK14 (0.57) | MAPK14PIP4K2ALCKLYNFRK | |
| SCHEMBL4697140 | 0.84 | BRAF (0.66) | MAPK14BRAF | |
| SCHEMBL4701699 | 0.83 | BRAF (0.70) | MAPK14BRAFRAF1PIP4K2ALCK | |
| SCHEMBL4699995 | 0.82 | BRAF (0.68) | MAPK14BRAF | |
| SCHEMBL4699786 | 0.79 | BRAF (0.63) | BRAFLYNABL1EGFRBCR | |
| SCHEMBL4787068 | 0.78 | BRAF (0.57) | BRAFABL1LMNAKDRBTK | |
| SCHEMBL12000876 | 0.77 | MAPK14 (1.00) | MAPK14MAPK11TP53 | |
| SCHEMBL4917626 | 0.76 | BRAF (0.58) | BRAFABL1KDRBTKCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275054-A1 | 3-(Substituted Amino)-Pyrazolo[3, 4-D]Pyrimidines as Ephb and Vegfr2 Kinase Inhibitors | HOLZER PHILIPP | 2008-11-06 | — | — | US | claimed |
| EP-1963327-A1 | 3-(SUBSTITUTED AMINO)-PYRAZOLO[3,4-d]PYRIMIDINES AS EPHB AND VEGFR2 KINASE INHIBITORS | Novartis AG (CH) | 2008-09-03 | — | — | EP | claimed |
| WO-2007062805-A1 | 3-(SUBSTITUTED AMINO)-PYRAZOLO[3,4-d]PYRIMIDINES AS EPHB AND VEGFR2 KINASE INHIBITORS | NOVARTIS AG (CH) | 2007-06-07 | — | — | WO | claimed |
| US-20080275054-A1 | 3-(Substituted Amino)-Pyrazolo[3, 4-D]Pyrimidines as Ephb and Vegfr2 Kinase Inhibitors | HOLZER PHILIPP | 2008-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275054-A1 | 3-(Substituted Amino)-Pyrazolo[3, 4-D]Pyrimidines as Ephb and Vegfr2 Kinase Inhibitors | EPHB3, EPHB2, EPHB1 | MAPK14 252/4885BRAF 42/4885RAF1 141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.