Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 7/20 | 0.70 |
| ▸ | IGF1R | P08069 | 7/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 4/20 | 0.44 |
| ▸ | PAK3 | O75914 | 3/20 | 0.44 |
| ▸ | PAK2 | Q13177 | 3/20 | 0.44 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694696 | 0.84 | NTRK1 (0.50) | NTRK1IGF1RJAK2JAK3PAK1 | |
| SCHEMBL4696446 | 0.84 | NTRK1 (0.49) | NTRK1IGF1RCCNE1CDK2JAK2 | |
| SCHEMBL4694125 | 0.83 | NTRK1 (0.48) | NTRK1IGF1RJAK2JAK3BRD4 | |
| SCHEMBL2634350 | 0.82 | NTRK1 (1.00) | NTRK1IGF1RJAK2JAK3 | |
| SCHEMBL56519 | 0.78 | IGF1R (0.63) | NTRK1IGF1RCDK2 | |
| SCHEMBL22535573 | 0.78 | PAK1 (0.51) | NTRK1IGF1RCCNE1CDK2JAK2 | |
| SCHEMBL22535327 | 0.77 | PAK1 (0.48) | NTRK1IGF1RCCNE1CDK2JAK2 | |
| SCHEMBL22535788 | 0.77 | PAK1 (0.48) | NTRK1IGF1RCCNE1CDK2JAK2 | |
| SCHEMBL4070121 | 0.76 | IGF1R (0.78) | NTRK1IGF1R | |
| SCHEMBL17044023 | 0.76 | NTRK1 (0.88) | NTRK1IGF1RJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |