Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1799107 | 0.86 | HRH3 (0.60) | HRH3HPGDKCNH2MET | |
| SCHEMBL1835474 | 0.86 | HRH3 (0.60) | HRH3HPGDKCNH2MET | |
| SCHEMBL2340098 | 0.83 | HRH3 (0.62) | HRH3KCNH2METATR | |
| SCHEMBL2340094 | 0.83 | HRH3 (0.62) | HRH3KCNH2METATR | |
| SCHEMBL966970 | 0.82 | SPHK2 (0.55) | HPGDCHRNB2CHRNA7CHRNA4L3MBTL3 | |
| SCHEMBL966968 | 0.82 | SPHK2 (0.55) | HPGDCHRNB2CHRNA7CHRNA4L3MBTL3 | |
| SCHEMBL970102 | 0.82 | SPHK2 (0.55) | HPGDCHRNB2CHRNA7CHRNA4L3MBTL3 | |
| SCHEMBL970043 | 0.81 | HPGD (0.49) | HRH3HPGDCHRNB2CHRNA7CHRNA4 | |
| SCHEMBL970042 | 0.81 | HPGD (0.49) | HRH3HPGDCHRNB2CHRNA7CHRNA4 | |
| SCHEMBL968549 | 0.81 | HPGD (0.49) | HRH3HPGDCHRNB2CHRNA7CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904442-A1 | HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007005503-A1 | HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-01-11 | — | — | WO | disclosed |