Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 15/20 | 0.77 |
| ▸ | PIM1 | P11309 | 2/20 | 0.60 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | PGK1 | P00558 | 1/20 | 0.60 |
| ▸ | CDK1 | P06493 | 1/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.60 |
| ▸ | GSK3A | P49840 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.60 |
| ▸ | CDK9 | P50750 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.60 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.60 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3037215 | 0.87 | FYN (1.00) | FYNPIM1CCNT1ABL1PGK1 | |
| SCHEMBL13234626 | 0.86 | FYN (0.76) | FYNPIM1CCNT1ABL1PGK1 | |
| SCHEMBL2949519 | 0.84 | FYN (0.77) | FYNPIM1CCNT1ABL1PGK1 | |
| SCHEMBL4694858 | 0.83 | FYN (0.75) | FYNPIM1CCNT1ABL1PGK1 | |
| SCHEMBL2951152 | 0.82 | FYN (0.79) | FYNPIM1CCNT1ABL1PGK1 | |
| SCHEMBL2947115 | 0.82 | FYN (0.73) | FYNPIM1CCNT1ABL1PGK1 | |
| SCHEMBL12761390 | 0.82 | FYN (1.00) | FYNPIM1CCNT1ABL1PGK1 | |
| SCHEMBL13234625 | 0.81 | FYN (1.00) | FYNPIM1CCNT1ABL1PGK1 | |
| SCHEMBL2950581 | 0.81 | FYN (0.72) | FYNPIM1CCNT1ABL1PGK1 | |
| SCHEMBL19467085 | 0.81 | FYN (0.72) | FYNPIM1CCNT1ABL1PGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |