Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.73 |
| ▸ | MEN1 | O00255 | 4/20 | 0.73 |
| ▸ | RAD52 | P43351 | 3/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.70 |
| ▸ | CDK1 | P06493 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | HPGD | P15428 | 5/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.64 |
| ▸ | USP2 | O75604 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.63 |
| ▸ | AURKA | O14965 | 9/20 | 0.63 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696845 | 1.00 | KMT2A (0.73) | KMT2AMEN1RAD52POLBCHEK1 | |
| SCHEMBL4520017 | 0.91 | KMT2A (0.85) | KMT2AMEN1RAD52POLBCHEK1 | |
| SCHEMBL4519934 | 0.91 | KMT2A (0.72) | KMT2AMEN1RAD52POLBCHEK1 | |
| SCHEMBL12355146 | 0.91 | KMT2A (0.76) | KMT2AMEN1RAD52POLBCHEK1 | |
| SCHEMBL4531850 | 0.89 | KMT2A (0.92) | KMT2AMEN1RAD52POLBCHEK1 | |
| SCHEMBL4751310 | 0.89 | KMT2A (0.68) | KMT2AMEN1RAD52POLBCHEK1 | |
| SCHEMBL4531234 | 0.89 | KMT2A (0.71) | KMT2AMEN1RAD52POLBCHEK1 | |
| SCHEMBL4527823 | 0.89 | KMT2A (0.68) | KMT2AMEN1RAD52POLBCHEK1 | |
| SCHEMBL4535665 | 0.89 | KMT2A (0.71) | KMT2AMEN1RAD52POLBCHEK1 | |
| SCHEMBL4524797 | 0.89 | KMT2A (0.68) | KMT2AMEN1RAD52POLBCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966217-A1 | NOVEL, ACYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | Bayer HealthCare AG (DE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007079862-A1 | NOVEL, ACYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2007-07-19 | — | — | WO | disclosed |