Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 10/20 | 0.39 |
| ▸ | RAF1 | P04049 | 8/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15432553 | 0.88 | SLC34A2 (0.47) | SLC34A2MAPK1HTR2AKCNH2KDM1A | |
| SCHEMBL6002086 | 0.88 | SLC34A2 (0.47) | SLC34A2HTR2AKCNH2KDM1AHDAC1 | |
| SCHEMBL47765 | 0.87 | SLC34A2 (0.46) | SLC34A2HTR2AKCNH2KDM1AHDAC1 | |
| SCHEMBL46734 | 0.87 | SLC34A2 (0.59) | SLC34A2MAPK1HTR2AKCNH2SCD | |
| SCHEMBL5999589 | 0.86 | SLC34A2 (0.44) | SLC34A2MAPK1HTR2AKCNH2SCD | |
| SCHEMBL6002088 | 0.85 | SLC34A2 (0.44) | SLC34A2MAPK1HTR2AKCNH2KDM1A | |
| SCHEMBL6002189 | 0.85 | SLC34A2 (0.44) | SLC34A2MAPK1HTR2AKCNH2KDM1A | |
| SCHEMBL6000194 | 0.85 | SLC34A2 (0.43) | SLC34A2MAPK1HTR2AKCNH2SCD | |
| SCHEMBL46989 | 0.85 | SLC34A2 (0.46) | SLC34A2HTR2AKCNH2KDM1AHDAC1 | |
| SCHEMBL5998740 | 0.85 | SLC34A2 (0.46) | SLC34A2HTR2AKCNH2KDM1AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |