Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 6/20 | 0.41 |
| ▸ | CCR1 | P32246 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | ACR | P10323 | 1/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.37 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698770 | 0.91 | KDM5B (0.40) | MAPK8KDM5BCCR1ADORA3ADORA2A | |
| SCHEMBL4697067 | 0.85 | PSEN1 (0.47) | MAPK8KDM5BADORA3ADORA2AADORA2B | |
| SCHEMBL4751605 | 0.84 | MAPK8 (0.41) | MAPK8KDM5BADORA3ADORA2AADORA2B | |
| SCHEMBL4755672 | 0.83 | PSEN1 (0.51) | MAPK8KDM5B | |
| SCHEMBL4700674 | 0.83 | KDM5B (0.39) | MAPK8KDM5BADORA3ADORA2AADORA2B | |
| SCHEMBL4700050 | 0.82 | KDM5B (0.36) | MAPK8KDM5BADORA3ADORA2AADORA2B | |
| SCHEMBL4697999 | 0.81 | PSEN1 (0.47) | MAPK8KDM5BADORA3ADORA2AADORA2B | |
| SCHEMBL4700824 | 0.81 | ACE (0.42) | MAPK8KDM5BADORA3ADORA2AADORA2B | |
| SCHEMBL4756625 | 0.80 | PSEN1 (0.45) | MAPK8KDM5BADORA3ADORA2AADORA2B | |
| SCHEMBL4755470 | 0.80 | PSEN1 (0.45) | KDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735285-B1 | PYRAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PROD INC (US) | 2008-07-23 | — | — | EP | claimed |