Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 4/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | BLK | P51451 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3085908 | 0.83 | MAPT (0.57) | MAPTLMNAGAARAB9ACYP2C9 | |
| SCHEMBL3300398 | 0.79 | MAPT (0.54) | MAPTLMNAGAARAB9ACYP2C9 | |
| SCHEMBL2313285 | 0.79 | MAPT (0.68) | PTGS1MAPTRAB9ALCKKIT | |
| SCHEMBL4697489 | 0.79 | MAPT (0.68) | PTGS1MAPTLMNARAB9ALCK | |
| SCHEMBL22025008 | 0.78 | MAPT (0.64) | PTGS1MAPTLMNARAB9APOLB | |
| SCHEMBL13472574 | 0.77 | MAPT (0.60) | MAPTLMNAGAARAB9ABTK | |
| SCHEMBL2492831 | 0.75 | PTGS1 (0.70) | PTGS1MAPTLMNARAB9ABTK | |
| SCHEMBL374471 | 0.75 | PTGS1 (0.70) | PTGS1MAPTLMNAGAARAB9A | |
| SCHEMBL4463935 | 0.75 | PTGS1 (0.89) | PTGS1MAPTLMNARAB9ABTK | |
| SCHEMBL15127740 | 0.74 | POLB (0.69) | PTGS1MAPTLMNARAB9ABTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963327-A1 | 3-(SUBSTITUTED AMINO)-PYRAZOLO[3,4-d]PYRIMIDINES AS EPHB AND VEGFR2 KINASE INHIBITORS | Novartis AG (CH) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007062805-A1 | 3-(SUBSTITUTED AMINO)-PYRAZOLO[3,4-d]PYRIMIDINES AS EPHB AND VEGFR2 KINASE INHIBITORS | NOVARTIS AG (CH) | 2007-06-07 | — | — | WO | disclosed |