Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | HTR1D | P28221 | 2/20 | 0.31 |
| ▸ | HTR1B | P28222 | 2/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1774930 | 1.00 | HRH4 (0.42) | HRH4KITDHFRPRKCQNUDT1 | |
| SCHEMBL1774270 | 0.85 | HRH4 (0.44) | HRH4KITDHFRPRKCQNUDT1 | |
| SCHEMBL1775193 | 0.85 | HRH4 (0.44) | HRH4KITDHFRPRKCQNUDT1 | |
| SCHEMBL1773848 | 0.85 | HRH4 (0.44) | HRH4KITDHFRPRKCQNUDT1 | |
| SCHEMBL1773986 | 0.83 | HRH4 (0.43) | HRH4KITPRKCQNUDT1MAPK13 | |
| SCHEMBL603504 | 0.83 | HRH4 (0.43) | HRH4KITPRKCQNUDT1MAPK13 | |
| SCHEMBL1775561 | 0.83 | HRH4 (0.43) | HRH4KITPRKCQNUDT1MAPK13 | |
| SCHEMBL1774922 | 0.82 | HRH4 (0.43) | HRH4DHFR | |
| SCHEMBL1773517 | 0.80 | HRH4 (0.41) | HRH4KITPRKCQNUDT1MAPK13 | |
| SCHEMBL1774470 | 0.80 | HRH4 (0.41) | HRH4KITPRKCQNUDT1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |
| EP-1966162-A2 | PYRIMIDINE DERIVATIVES | Pfizer Limited (GB) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007072163-A2 | PYRIMIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |