Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | UBE2N | P61088 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 10/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4532810 | 0.82 | AURKA (0.48) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL6749032 | 0.82 | AURKA (0.55) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4531686 | 0.82 | AURKA (0.55) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL6749031 | 0.81 | AURKA (0.54) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4525589 | 0.81 | AURKA (0.54) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4699375 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL14467241 | 0.79 | TNK2 (0.56) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4540012 | 0.79 | CHEK1 (0.44) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL1785983 | 0.78 | TNK2 (0.54) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4698505 | 0.78 | AURKA (0.46) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008131858-A2 | USE OF ACYCLICALLY SUBSTITUTED FUROPYRIMIDINE DERIVATIVES FOR TREATING PULMONARY ARTERIAL HYPERTONIA | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-11-06 | — | — | WO | disclosed |
| EP-1966217-A1 | NOVEL, ACYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | Bayer HealthCare AG (DE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007079862-A1 | NOVEL, ACYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2007-07-19 | — | — | WO | disclosed |