Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 15/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 8/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 6/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.40 |
| ▸ | KDM1A | O60341 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3744987 | 0.83 | DPP4 (0.39) | GABRR1DPP4DPP7DPP9DPP8 | |
| SCHEMBL3742246 | 0.83 | DPP4 (0.39) | GABRR1DPP4DPP7DPP9DPP8 | |
| SCHEMBL3739853 | 0.81 | DPP4 (0.55) | DPP4DPP7DPP9DPP8KDM1A | |
| SCHEMBL3739847 | 0.81 | DPP4 (0.55) | DPP4DPP7DPP9DPP8KDM1A | |
| SCHEMBL3742247 | 0.80 | GABRR1 (0.37) | GABRR1DPP4DPP7DPP9DPP8 | |
| SCHEMBL3753373 | 0.80 | DPP4 (0.43) | DPP4DPP7DPP9DPP8 | |
| SCHEMBL3753372 | 0.80 | DPP4 (0.43) | DPP4DPP7DPP9DPP8 | |
| SCHEMBL3753374 | 0.80 | DPP4 (0.43) | DPP4DPP7DPP9DPP8 | |
| SCHEMBL3745322 | 0.78 | DPP4 (0.47) | DPP4DPP7DPP9DPP8 | |
| SCHEMBL3754826 | 0.78 | DPP4 (0.39) | DPP4DPP7DPP9DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919854-A2 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2008-05-14 | — | — | EP | claimed |
| WO-2007027651-A2 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2007-03-08 | — | — | WO | claimed |
| EP-1919854-A2 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007027651-A2 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2007-03-08 | — | — | WO | disclosed |